Suchergebnisse

This report encompasses the development of Australia-Latin America relations from a historical perspective. At the outset, a comprehensive definition of "Latin America" and the socio-econopolitical framework is provided to assist the general knowledge about Latin America before the Australia-Latin America relations and foreign policy is discussed. This is done in a chronological manner, in order of the key political, social, economic events that took place in Latin America. The importance of the political framework in particular is important when discussing the Australia-Latin America relations. It was innovating and interesting to discuss the relationship in terms of Australia's foreign policy. This is an area the academic scholars have not yet discovered, thus, it was challenging and limited in terms of resources. The fact was that Latin America was entirely out of discussion in Howard's foreign policy, and this was difficult to link back in terms of relationship. Thus, it was my analysis in Chapter 2 by observing Australian political climate derived from foreign policy under the Howard government. The shift in attitude under the new government was the most enjoyable part of the report. It was interesting to link the shift of political atmosphere under the Rudd government and the change of attitude towards Latin America. As a consequence, immense changes occurred in the relationship. The biggest challenge was dealing with broadness of the report. The purpose of this report is to grasp general understanding and knowledge in Australia-Latin America relations by examining the historical trajectory of Australian foreign policy. This report has historical perspective, but throughout the report, it contains much political views and analysis. By looking at how the significant changes occurred in the relationship, it will help in many ways to advance the future relationship.

Drawing on two multilingual qualitative datasets (Korean/English and German/English), this paper examines the dual role and positionalities of two researchers who simultaneously act as translators, as well as the implications of this dual role for multilingual qualitative research. This work is informed by transnational feminist translation studies and transnational feminist approaches to qualitative research, and founded on the two researchers' intimate familiarity with their participants' languages, contexts, and meaning-making processes. Considering the complexity of this familiarity, this work presents unique dilemmas—challenges and opportunities—with respect to translating, representing, and writing about multilingual qualitative data.

Abstract
Background
For landscape-level risk assessments of pesticides, the choice of the scenario is a key question, since it determines the outcome of a risk assessment. Typically, the aim is to select a realistic worst-case scenario. In the present study, landscapes from an area with a high proportion of cereal fields in France were analysed and simulations with population models for wood mouse, common vole, brown hare and European rabbit were conducted to understand if the worst-case character regarding pesticide exposure and population survival can be determined based on landscape features alone. Furthermore, it was analysed which landscape features relate with population survival and the magnitude of effects due to pesticide application. Answers to these question may help to decide whether landscape scenarios can be selected based on expert decision and whether the same scenarios may be used for different species or not.

Results
There were species-specific landscape features relating to long-term population survival. A landscape that is worst-case for one species, was not necessarily worst-case for another. Furthermore, landscapes that were worst-case regarding population survival were often not worst-case regarding the magnitude of effects resulting from pesticide application. We also found that small landscapes were sometimes, but not always worst-case compared to larger landscapes. When small landscapes were worst-case, this was typical because of the artificial borders of the digitised landscape.

Conclusions
Landscape analyses can help to obtain an approximate impression of the worst-case character of a landscape scenario. However, since it was difficult to consistently and reliably do this for single landscapes, it may be advisable to use a set of different landscapes for each risk assessment, which covers the natural variability. Depending on whether population survival shall be ensured or the magnitude of effects due to pesticides, different landscape structure and composition needs to be considered to establish a worst-case landscape scenario.

INTRODUCTION: Tumor necrosis factor (TNF-alpha) inhibitors, such as adalimumab, have shown success in treating autoimmune inflammatory diseases but are associated with substantial financial burdens to the healthcare system. Biosimilars, which are highly similar to biologic agents, offer the potential to reduce the financial burden of treatment. In the case of TNF-alpha inhibitors, they may also offer improved stability and enable prolonged use. SB5, an adalimumab biosimilar, has shown equivalent efficacy and comparable safety to its reference product in clinical trials. Currently, SB5 is approved for storage for 36 months at 2–8 °C and may be stored at room temperature (25 °C) for a maximum period of 14 days. The objective of this study was to evaluate the stability of SB5, aged to its shelf-life of 36 months, at room temperature (25 ± 2 °C) and 60 ± 5% relative humidity (RH) for a period of 4 weeks, which is longer by 14 days than that of SB5 currently approved in the European Union. METHODS: This study evaluated the stability of SB5, aged to its shelf-life of 36 months, at room temperature (25 ± 2 °C) for a period of 4 weeks. Three independent batches of 36 months-aged SB5 were stored at 25 ± 2 °C and 60 ± 5% RH for 4 weeks. Samples were tested at 0, 2, and 4 weeks. RESULTS: Color, clarity, visible particles, pH, protein concentration, and particulate matter were consistent among the batches, and all the test results met the acceptance criteria at each time point. Percent charge variance was maintained over time. Percent of high molecular weight species detected, total purity, relative binding activity by TNF-alpha, and relative potency by TNF-alpha neutralization did not change over time within each batch, and all values were within the acceptance criteria limits. CONCLUSION: SB5 aged for 36 months is physicochemically and biologically stable for 4 weeks at 25 ± 2 °C and 60 ± 5% RH, which is 2 weeks longer than the alternative storage condition as approved by the European Medicines Agency, which is at 25 °C ...

Abstract
Background and Purpose - The purpose of this paper is to empirically analyse the effects of sustainability-oriented innovation practices on the overall organizational performance. Further, this paper also aims to advance understanding of the measurement of corporate sustainability practices with the focus on innovation dimensions. Design/Methodology/Approach - The study uses data obtained from a survey of 116 organizations encompassing both the manufacturing and service industries in Slovenia. Descriptive statistics were used in order to determine the level of sustainability-oriented innovation practices deployment. Exploratory factor analysis was applied to extract the underlying factors and to provide a basis for assessing their reliability and validity. In addition, regression analysis was used to quantify the effect of sustainability practices on the organizational performance. Results - Data analysis result showed that sustainability-oriented innovation practices are significantly associated with organizational performance. Therefore, empirical evidence from this research confirmed the premise that building innovation competencies and integrating innovation activities in organization's processes lead to performance benefits. This contributes to the debate about the potential for organizations to be sustainable and competitive. Conclusion - The presented research on corporate sustainability provides important theoretical and practical insights on which the deployment of sustainability-oriented innovation practices are conducive to fostering a broader set of performance benefits. As such, managers should increase organizations' capacity for innovation which can be beneficial in terms of performance implications and achieving sustainability goals

AbstractThe okadaic acid (OA)-group toxins, including OA, dinophysistoxin-1 (DTX1), dinophysistoxin-2 (DTX2), and dinophysistoxin-3 (DTX3), cause diarrheic shellfish poisoning in humans. To manage OA-group toxins more strictly, Korean regulations were recently revised to consider OA, DTX1, DTX2, and DTX3 combined. Thus, our study characterized the occurrence of OA, DTX1, DTX2, and DTX3 in seafood distributed across South Korea, and a risk assessment of seafood consumption was conducted. Two hundred and seventeen samples from 16 bivalve and 7 non-bivalve species collected from three representative coastal areas in 2021 were analyzed via liquid chromatography-tandem mass spectrometry. OA, DTX1, and DTX3 were detected in 2.3%, 4.1%, and 9.2% of the examined samples, with positive mean levels of 11.3, 16.4, and 40.9 µg/kg, respectively. DTX2 was not detected in any of the samples. At least one OA-group toxin was detected in the bivalve samples, including blood clams, pan shells, hard clams, mussels, and scallops, whereas none were detected in non-bivalves. The estimated acute exposure to OA-group toxins through the intake of seafood in the Korean population and consumer groups was low, ranging from 24.7 to 74.5% of the recommended acute reference dose (ARfD) of 0.33 μg OA equivalents/kg body weight. However, for the scallop consumers aged 7–12 years, acute exposure to OA-group toxins exceeded the ARfD, indicating a possible health risk. These results suggest that including DTX3 in the new regulatory limits is appropriate to protect Korean seafood consumers from exposure to OA-group toxins.